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4 (Tussue NEMATODE ) Causes ; LYMPHATIC FILARIASIS “™. as]. s/- cases Woucherena Brugia malas! bancrafe’ ¢ Atco coursed y BRUGIA TIMOR! — not found in INDIA (but in INDONESIA) 9 Aes nuclei im TAIL DEFINATIVE MOSt > HUMANE 7 220 pm INTERMEDIATE HOST: MOSMUITOES > SKEATHED @ NOéctTORWAL \ Mesauite VECTOR * masauito vECWR: mMmansonia Culex Fatigens / c. quingue fasciatus annulifero Culex tra tacnorgncus f SovTHERN House Mosauito INFECTIVE STAGE FOR Humans Cant in mosaurto) is: 314 svAge FILARIFORM LARVA 1 Geposited on sein penetrate sxint SURCUTANEOUS TiSSDE ALL USSUE NEMATODES v { % are wiviPaRous Lampn nopes e worrns (e produces v a Larvae & NOT * : eaas LemPHat® yesséts —» Adulte are Formed Keré& & FEtivization accuns ce LARVAE ¢L---* y Hlos st sence eh mictornarine ” . ngrective conm /srace Fieanieoan Mos auito ’ T mosauit Larva (cL) VS OSE US Enter svstemic ceneue’ and cence FL | gt4 siace Fe CYCLO DEVELOP Me ITAL CYCLE Canta CHCLOPROPAGATIVE CYCLE Seen in MALARIA) Routs . recponsible for OISEAce + MICROFILARIAE ARE rMmP- FoR OinaNOs? 1 ‘Inftommation of Lymonatic vesers = vvMnpwawaitic (ingitteation of txmenatic vessiis , PLASMA CELLS, EosisePUits, Mecropmacs t Proricee™ oF ~ 4 Enpotne AL Conosective ces TISSUE * Tovtuosity and damage to vétiets & LYMPHADEMA GF Limes & Recurrent attacks of bgraphangitt L cwyldus AC THAITiS . > LYMPHATIC sas teu® cHY¥LoUs ASAE al CHYLOLOEL (oye- Wucnenin @ancnorti) LY MP Ass alovARDE CHYLURIA aT tad J’ = rupture of +| release Vw Ce Lymeu * NOCTURNAL PERIODICITY Dam -2pm: MiceoeAgiAg of w-bancvofti ave veteased into BioODSTRE Ay) BccuLT FLLARinsiC): “aes. TROPICAL PULTMONMRY EOSINOPKILA (x08) / WEINGARTENS Sy¥NoRome * be nypensensitivity gx%? ro ANTIGENS GF MICROFILARIAE + MICROFILARIAE vapidty cleaved fram GLadd ¢ Filtered , Lovgen & destreyed in Lunsas AA . no micrafiloviae in Goad cle : -~WwoetuR NAL PAROXYSMAL CouEH - WHEEZING ORLE : Female = 4:4 ~Low GRADE FEVER ~ seen mfety ig 3°! DEcAne — Loss OF WHAT OF LiFe = occasionally micsefilavioe are entrapped i - > [7 2) SPLEEN HEPA TOSPLEWOME GAU R UN > wmev n- me tas roevers KouweNmag synoKome iy “smenpues ; BLOOD , HYDROCOEL FLUID, URINE By BIREer Wer AMOUNT: - Serpentine movement of microfilariag con be appreciated By -wiex 61000 smear exnmin® Th cone: teemaves oF @1DaD = Gem 7 MEMBRANE FUTeation -tecHNIaVE ~HRE A UNorts CENTRIFUGATION Téchniave “ Di- ETHYL CARCAMAZEPINE wt xy TAGLET oF microF. > — Blwoo DEC orally Enter BroopsStREAM SAmeres examined (2 mg leg, Booy wt) in 30 min LOA -LOA iNFection c]t in < ONCHOCERtA VOLVULUS INFECTION D> Guawerarie avery cont b+ BLOOD CAMPUS : CENTRIFUGED & Stammseo E Acridine Oronge ' | SEEN UNDER FLUSRECCENT MF. RP MICRGFILARIAE ave ABSENT in TBL60D in: - chronic Flaviasis 7 occult filariasis + USRONG TIME SF BlevD coLLECtioN Sp Ag verection + monoclonal Abe apainst (Og4cs and ADAQ anncenss by ELISA and TeT | > sentitive ~ can be done in any Hme of DAY 7 Aft byw curcent & past infec” 4 can also be done on URINE Uy AB: vereetion > €LISh N how specibeel 7 UF ‘t > tH Ky Pek CA specific , 4 sensitive) can detect even 2 microriARiA / Lm of 81000