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CHEMISTRY OF NATURAL PRODUCT
(MPC 104T)
ASSIGNMENT
TOPIC – Chemistry & Physiological significance of
Vitamin E
Session – 2020 - 21
SUBMITTED TO - SUBMITTED BY- Prof. N.S. Hari Narayana Moorthy RAM RUDRA SAHU (Dept of pharmacy) M.Pharmacy 1st^ sem. (Pharma. Chem.)
❖ Definition of Vitamin :-
thus, conserved by the organism; whereas storage of th
The structure and synthesis of ___ - tocopherol were reported in 1938.Since then, several other closely related compounds have been discovered from natural sources, and this family of natural products took the generic name tocopherols. The term tocol is the trivial designation for 2-methyl- 2 - (4,8, trimethyltridecyl)chroman- 6 - ol (I, R^1 = R^2 = R^3 = H) ✓ Vitamin E is a vitamin that dissolves in fat. ✓ It is found in many foods including vegetable oils, meat,poultry,egg,fruits,vegetables and wheat germ oil. ✓ It is also available as a supplements.
Tocotrienols have only a single chiral center, which exists at the 2' chromanol ring carbon, at the point where the isoprenoid tail joins the ring. The other two corresponding centers in the phytyl tail of the corresponding tocopherols do not exist as chiral centers for tocotrienols due to unsaturation (C-C double bonds) at these sites. Tocotrienols extracted from plants are always dextrorotatory stereoisomers, signified as d-tocotrienols. In theory, levorotatory forms of tocotrienols (l-tocotrienols) could exist as well, which would have a 2S rather than 2R configuration at the molecules' single chiral center, but unlike synthetic dl-alpha- tocopherol, the marketed tocotrienol dietary supplements are all d- tocotrienol extracts from palm or annatto oils.
- PRODUCTS – Vitamin E is available from numerous sources as oral capsules, liquids, and tablets under various names. Vitamin E is also available as a component of numerous multivitamin preparations. The forms of vitamin E used in the commercial products. Vitamin E activity is currently expressed in terms of the (+)-Alpha- tocopherol equivalents based on the former USP units and mass. One former USP unit is equal to one former IU. ▪ Table - Relative Potencies of Various Commercial Forms of Vitamin E - Form of Vitamin E Potency Potency (in former USP units) of 1 mg (+)- Alpha - Tocopherol 1. (+)- Alpha - Tocopherol acetate 1 (+)- Alpha - Tocopherol acid succinate 0. (+)- Alpha - Tocopherol 1. (+)- Alpha - Tocopherol acetate 1. (+)- Alpha - Tocopherol acid succinate 1.
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