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Detailed notes on the anatomy and physiology of the urinary system, including the structure and functions of the kidneys, ureters, bladder, and urethra. It covers topics such as the processes of urine formation, the regulation of urine concentration and volume, and the physical and chemical characteristics of urine. The document also discusses the innervation and endocrine functions of the kidneys, as well as the mechanisms of micturition (urination). This comprehensive overview of the urinary system would be valuable for students studying anatomy and physiology, particularly those in courses related to the renal system.
Typology: Summaries
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Kidneys - major excretory organs Ureters - transport urine from kidneys to urinary bladder Urinary bladder - temporary storage reservoir for urine Urethra - transports urine out of the body
Retroperitoneal, in the superior lumbar region; around T12 to L Right kidney is crowded by the liver and is lower than the left kidney Adrenal (suprarenal) gland atop each kidney Convex lateral surface, concave medial surface Ureters, renal blood vessels, lymphatics, and nerves enter and exit at the hilum
Renal cortex - granular-appearing superficial region Renal medulla - composed of cone-shaped medullary (renal) pyramids, separated by renal columns (inward extensions of cortical tissue) Papilla - tip of the pyramid; releases urine into minor calyx Lobe - medullary pyramid and its surrounding cortical tissue; approximately 8 per kidney Renal pelvis - funnel-shaped tube continuous with the ureter Minor calyces - drain the pyramids at the papillae Major calyces - collect urine from the minor calyces and empty it into the renal pelvis Urine flow : Renal pyramid → minor calyx → major calyx → renal pelvis → ureter
Kidneys cleanse the blood and adjust its composition; they have a rich blood supply. Renal arteries deliver approximately 1/4 (1200 ml) of the cardiac output to the kidneys each minute. Arterial flow into and venous flow out of the kidneys follow similar paths. Nerve supply via sympathetic fibers from the renal plexus.
Regulating total water volume and total solute concentration in the body fluids Regulating extracellular fluid ion concentrations Ensuring long-term acid-base balance Removal of metabolic wastes (especially nitrogen-containing molecules), toxins, and drugs Endocrine functions: Renin - regulation of blood pressure Erythropoietin - regulation of red blood cell production Activation of vitamin D Gluconeogenesis during prolonged fasting
Structural and functional units that form urine More than 1 million per kidney Two main parts: Renal corpuscle Renal tubule
Two parts: Glomerulus - a tuft of capillaries with fenestrated endothelium, allowing filtrate formation Glomerular capsule (Bowman's capsule) - a cup-shaped, hollow structure surrounding the glomerulus
Glomerular capsule: Parietal layer - simple squamous epithelium Visceral layer - branching epithelial podocytes with foot processes that cling to the basement membrane Three parts: Proximal convoluted tubule - main function is reabsorption Nephron loop - dips from the cortex down into the medulla, with descending and ascending limbs Distal convoluted tubule - main function is secretion
180 L of fluid is processed daily, but only 1.5 L of urine is excreted (less than 1% of what is filtered). Kidneys filter the body's entire plasma volume 60 times each day. Three processes in urine formation and adjustment of blood composition: Glomerular filtration - produces a cell- and protein-free filtrate
Ureters have three layers: mucosa (transitional epithelium), muscularis (smooth muscle), and adventitia (fibrous connective tissue). Urinary bladder is a muscular sac for temporary storage of urine, located on the pelvic floor. Urethra is a muscular tube draining the urinary bladder, with different regions in males and females.
Urination or voiding requires the simultaneous occurrence of three events: Contraction of the detrusor muscle by the autonomic nervous system Opening of the internal urethral sphincter by the autonomic nervous system Opening of the external urethral sphincter by the somatic nervous system