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The Cell: A Molecular Approach, Seventh Edition, Exercises of Medicine

The Cell: A Molecular Approach, Seventh Edition. Geoffrey M. Cooper and Robert E. Hausman. Part I. Fundamentals and Foundations. 1. An Overview of Cells and ...

Typology: Exercises

2021/2022

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The Cell: A Molecular Approach, Seventh Edition
Geoffrey M. Cooper and Robert E. Hausman
Part I. Fundamentals and Foundations
1. An Overview of Cells and Cell Research
The Origin and Evolution of Cells
Cells as Experimental Models
Tools of Cell Biology
Key Experiment: HeLa Cells
Molecular Medicine: Viruses and Cancer
2. Molecules and Membranes
The Molecules of Cells
Enzymes as Biological Catalysts
Cell Membranes
Key Experiment: The Folding of Polypeptide Chains
Key Experiment: The Structure of Cell Membranes
3. Bioenergetics and Metabolism
Metabolic Energy and ATP
Electron Transport and Oxidative Phosphorylation
Photosynthesis
The Biosynthesis of Cell Constituents
Key Experiment: The Chemiosmotic Theory
Key Experiment: Antimetabolites and Chemotherapy
4. Fundamentals of Molecular Biology
Heredity, Genes, and DNA
Expression of Genetic Information
Recombinant DNA
Detection of Nucleic Acids and Proteins
Gene Function in Eukaryotes
Key Experiment: The DNA Provirus Hypothesis
Key Experiment: RNA Interference
5. Genomics, Proteomics, and Systems Biology
Genomes and Transcriptomes
Proteomics
Systems Biology
Key Experiment: The Human Genome
Molecular Medicine: Malaria and Synthetic Biology
Part II. The Flow of Genetic Information
6. Genes and Genomes
The Structure of Eukaryotic Genes
Noncoding Sequences
Chromosomes and Chromatin
Key Experiment: The Discovery of Introns
Key Experiment: The ENCODE Project
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The Cell: A Molecular Approach , Seventh Edition

Geoffrey M. Cooper and Robert E. Hausman

Part I. Fundamentals and Foundations

1. An Overview of Cells and Cell Research The Origin and Evolution of Cells Cells as Experimental Models Tools of Cell Biology Key Experiment: HeLa Cells Molecular Medicine: Viruses and Cancer 2. Molecules and Membranes The Molecules of Cells Enzymes as Biological Catalysts Cell Membranes Key Experiment: The Folding of Polypeptide Chains Key Experiment: The Structure of Cell Membranes 3. Bioenergetics and Metabolism Metabolic Energy and ATP Electron Transport and Oxidative Phosphorylation Photosynthesis The Biosynthesis of Cell Constituents Key Experiment: The Chemiosmotic Theory Key Experiment: Antimetabolites and Chemotherapy 4. Fundamentals of Molecular Biology Heredity, Genes, and DNA Expression of Genetic Information Recombinant DNA Detection of Nucleic Acids and Proteins Gene Function in Eukaryotes Key Experiment: The DNA Provirus Hypothesis Key Experiment: RNA Interference 5. Genomics, Proteomics, and Systems Biology Genomes and Transcriptomes Proteomics Systems Biology Key Experiment: The Human Genome Molecular Medicine: Malaria and Synthetic Biology **Part II. The Flow of Genetic Information

  1. Genes and Genomes** The Structure of Eukaryotic Genes Noncoding Sequences Chromosomes and Chromatin Key Experiment: The Discovery of Introns Key Experiment: The ENCODE Project

7. Replication, Maintenance, and Rearrangements of Genomic DNA DNA Replication DNA Repair DNA Rearrangements Molecular Medicine: Colon Cancer and DNA Repair Key Experiment: Rearrangement of Immunoglobulin Genes 8. RNA Synthesis and Processing Transcription in Bacteria Eukaryotic RNA Polymerases and General Transcription Factors Regulation of Transcription in Eukaryotes Chromatin and Epigenetics RNA Processing and Turnover Key Experiment: Isolation of a Eukaryotic Transcription Factor Key Experiment: The Discovery of snRNPs 9. Protein Synthesis, Processing, and Regulation Translation of mRNA Protein Folding and Processing Regulation of Protein Function Protein Degradation Molecular Medicine: Alzheimer’s Disease Key Experiment: The Discovery of Tyrosine Kinases **Part III. Cell Structure and Function

  1. The Nucleus** The Nuclear Envelope and Traffic between the Nucleus and the Cytoplasm The Organization of Chromosomes Nuclear Bodies Molecular Medicine: Nuclear Lamina Diseases Key Experiment: Identification of Nuclear Localization Signals 11. Protein Sorting and Transport: The Endoplasmic Reticulum, Golgi Apparatus, and Lysosomes The Endoplasmic Reticulum The Golgi Apparatus The Mechanism of Vesicular Transport Lysosomes Key Experiment: The Signal Hypothesis Molecular Medicine: Gaucher Disease 12. Mitochondria, Chloroplasts, and Peroxisomes Mitochondria Chloroplasts and Other Plastids Peroxisomes Molecular Medicine: Diseases of Mitochondria: Leber’s Hereditary Optic Neuropathy Molecular Medicine: Peroxisome Biogenesis Disorders 13. The Cytoskeleton and Cell Movement Structure and Organization of Actin Filaments Myosin Motors Microtubules Microtubule Motors and Movement Intermediate Filaments Key Experiment: The Isolation of Kinesin Key Experiment: Expression of Mutant Keratin Causes Abnormal Skin Development