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1. EXECUTIVE SUMMARY
The project "SURVEY OF VARIOUS GENERIC MEDICINES IN MARKET AND SUBMISSION OF REPORT" was undertaken as part of academic requirement of 4 years of b pharmacy course. PROJECT OBJECTIVES ARE AS FOLLOWS : โ To study the awareness of generic medicines amongst doctors , chemists and distributors โ To study difference between generic and branded medicines. โ To study the detailed information about generic drug. 10 INDIAN GENERIC DRUGS PRODUCERS ARE : I. Sun pharmaceutical industries II. Dr. Reddys laboratories III. Lupin IV. Ranbaxy V. Aurobindo VI. Glenmark VII. Wockhardt VIII. Torque pharmaceuticals IX. Hospira Page No : 1
INTRODUCTION OF THE PROJECT
GENERIC DRUGS :
A generic drug is identical or bioequivalent to a brand drug in dosage form , strength ,route of administration ,quality,performance, characteristics and intended use a) Generic drugs are allowed for sale after the patent on the original drug expire because active chemical present is same. b)Although they may not be associated with a particular company , generic drugs are usually subjected to government regulations in the countries in which they are dispensed c) They are labeled with the name of the name of manufacturer and a generic Nonproprietary name (ie. the name of the active ingredients in medicine that is decided by the expert committee and is understood internationally ) Example: paracetamol or acetaminophen is the nonproprietary name of medicine and which is sold by the proprietary name or brand name as crosin , dola 650 Page no :
1. In todays era the scope of generic drugs is
increasing day by day specially in several ill
health conditions such as diabetes ,
cardiovascular and microbial diseasrs โฆ.etc
2. When any patent expires it allows generic
manufacturer to prepare and develop
regulatory procedures
3. The scope is also increases due to para IV
fillings and bipolar provisions
4. So the scope of generic manufacturing also
increase.
BASIC GENERIC DRUG REQUIREMENTS :
โ Same active ingredients.
โ Same route of administration
โ Same dosage form
โ Same strength
โ Same condition of use
โ Inactive ingredient already approved in
similar NDA
Page no 4
GENERIC MEDICINES Page no 5
1) PARACETAMOL :
Generic name: paracetamol/acetaminophen
Brand name : Crocin,Metacin,Meftal,Tylenol and dolo 650 โฆ.etc Medicinal uses : Antipyretic, painkiller. Mechanism of Action : Paractetamol ( acetaminophen) Penetrates the blood brain barrier Inhibit cyclooxygenase (cox)enzyme AND blocks the formation and release of prostaglandin(PGE)in CNS AND ANTIPYRETIC EFFECT
Route of administration : oral , rectal and IV
Generic name : Albuterol Brand name : asthalin repsule (1000rs) ,ventolin(128rs Uses : relieve symptoms of asthma and chronic obstructive pulmonary disease (COPD) Mechanism of action : Albuterol acts on beta- 2 adrenergic receptors to relax the bronchial smooth muscle. Route of administration : normally delivered through the inhaled route while intravenous salbutamol is used when children are unresponsive to inhaled treatment. Page no 7 DOSE : 4mg tab 3 or 4 times per day and 2.5miligrams in adults inhalation. Company : cipla
PRICE : Rs 10 /strip brand price: budetrol(254rs) Side effects ; headache. โ feeling nervous, restless, excitable and/or shaky. โ fast, slow or uneven heartbeat. โ bad taste in the mouth. โ dry mouth. โ **Contraindications : overactive thyroid gland, diabetesโฆ.etc Page no 8
- Ascorbic acid ;**
โ vomiting,
โ heartburn,
โ stomach cramps, and
โ Headache
Contraindication : Diabetics,
patients prone to recurrent renal calculi
PRICE : LIMCEE 500MG =19 RS , MILCEE- Z = 40RS
Page no 10
4) Aspirin :
Generic Name : acetylsalicylic acid , ASPIWELL-75,
Aspergum , bufferin.
Brand Name : Ecosprin, Sprin, Aspro, Eprin and
Delisprin. Uses : Daily low-dose aspirin is a blood thinning medicine. Aspirin is known as a salicylate and a nonsteroidal anti-inflammatory drug (NSAID).analgesic, antipyretic Mechanism of action: Mainly blocks the prostaglandin. acetyl group of acetylsalicylic acid binds with a serine residue of the cyclooxygenase- 1 (COX-1) enzyme, leading to irreversible inhibition. Route of administration: the oral, rectal, and intravenous (IV) route Dosage: It is available in different doses, the lowest being 81 mg, also called a baby aspirin. Page no 11
Generic name : Zyrtec , cetirizine hydrochloride
Brand name: Cetzine Tab Glaxosmithkline Alerid 10 mg Tablet 10s Cipla Cetcip 10 mg Tablet 10s Cipla Cetrine Tab Dr. Reddy Uses: it is an antihistamine used to treat both seasonal and perennial allergy Symptoms like : watery eyes , runny nose, itching eyes,sneezing also use to treat hives (skin rashes) Mechanism of action : non-sedating antihistamine that works by blocking histamine (H-1) receptors on cells. Dose: use this drug exactly as directed on label or prescribed by your doctor. you may take it with or
without food .The chewable tablet must be chewed before you swallow it
Side effects:
โ feeling sleepy and tired. โ headaches. โ dry mouth. โ feeling sick (nausea) โ feeling dizzy. โ stomach pain. Contraindications: โ glaucoma, an increased pressure in the eye. โ liver problems. โ decreased kidney function. PRICE : Cetzine Tab Glaxosmithkline 17. Alerid 10 mg Tablet 10s Cipla 17. BRAND PRICE: CZ-3 (LUPIN)= 16RS
Dose : tablet 250mg and 500mg , oral suspension
100mg/5mL and 200mg/5mL
Side effects :
diarrhea.
nausea.
abdominal (belly) pain.
vomiting.
headache.
Contraindications: slow heartbeat,
low amount of magnesium in the blood.
low amount of potassium in the blood.
PRICE: 80 rs
Brand prices: 671 Rs( 500mg : PCD pharma )
7) omeprazole :
Generic name: Prilosec
Brand name: Ometab 20 Tab (INTAS) , Lomac 20
mg Tablet(Cipla)
Uses : indigestion and heartburn and acid reflux.
It's also taken to prevent and treat stomach
ulcers
Mechanism of action: proton pump inhibitor
route of administration : an intravenous infusion
for 20- 30 minutes , oral โฆ
Dose : Doctors suggest taking omeprazole 30 โ 60
minutes before a mealTrusted Source. If the
doctor recommends taking omeprazole twice
daily, the person should take it before breakfast
and before supper.
8) Atorvastatin :
Generic name: atorvastatin , fluvastatin
Brand name : Lipitor
Uses : used to treat high cholesterol. It is
marketed as a calcium salt under the brand
name Lipitor (atorvastatin calcium).
Mechanism of action: it is type of statin that
lowers the level of cholesterol in the blood. All
statins, including atorvastatin, prevent the
production of cholesterol in the liver by blocking
HMG-CoA reductase, an enzyme that makes
cholesterol.
Route of administration : orally
DOSE : 10 mg, 20 mg , 40 mg ,80 mg
Side effects: Joint pain, Insomnia ,
Urinary tract infection, Nausea.
Loss of appetite
Contraindications:Hypersensitivity to
atorvastatin.
Your doctor should not prescribe this
medication if you are a patient with liver
problems.
PRICE :1) lipvas 10mg = 57 Rs (elder
pharmaceutical company)
2) Atortaj 10mg = 53 Rs
20mg = 113Rs
40mg= 211Rs
Brand PRICE: stator 20mg = 140Rs
, caat 20 mg = 209 Rs ( Abbott) , Nutova 10mg =
750 Rs ( rechelist pharma )
