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Sample/practice exam 12 November 2016, questions, Exams of Pharmaceutical Chemistry

University of HertfordshirePharmaceutical Chemistry

Drug Design/Medicinal Chemistry Practice Questions

Typology: Exams

2018/2019

Uploaded on 12/11/2019

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UNIVERSITY OF HERTFORDSHIRE PROGRESS TEST PAPER
Session: 2017/18
Semester: A /B
SCHOOL OF LIFE & MEDICAL SCIENCES
DEPARTMENT OF PHARMACY, PHARMACOLOGY AND POSTGRADUATE MEDICINE
Pharmaceutical Science
Module Code: 5LMS0059
Methods in Drug Design: PROGRESS TEST
DURATION OF PROGRESS TEST: 1 HOUR
THE FOLLOWING IS PROVIDED FOR THIS EXAMINATION:
ONE question paper
ONE MCQ answer sheet
ONE short answer book
INSTRUCTIONS TO CANDIDATES:
The examination paper is divided into two parts.
Section A carries one half (50%) of the marks.
Section B carries one half (50%) of the marks.
Answer ALL the questions in Section A and ALL questions from Section B.
Section A consists of 20 multiple choice questions
Mark your answer to each question against the corresponding number on the MCQ
ANSWER SHEET. For example, if you think the answer to question 12 is [C] mark your
answer as follows: 12 [A] [B] [C] [D] [E]. Use an HB pencil and make your mark
like this NOT a or X or O. Erase all errors thoroughly. If you choose more than one
option for a question, you will receive NO marks for that question. Mark your exam number
on the answer sheet. Indicate the module title and code on the sheet.
Section B consists of one short answer question.
Answer the question in the answer book provided.
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Download Sample/practice exam 12 November 2016, questions and more Exams Pharmaceutical Chemistry in PDF only on Docsity!

UNIVERSITY OF HERTFORDSHIRE PROGRESS TEST PAPER

Session: 2017/ Semester: A /B SCHOOL OF LIFE & MEDICAL SCIENCES DEPARTMENT OF PHARMACY, PHARMACOLOGY AND POSTGRADUATE MEDICINE Pharmaceutical Science Module Code: 5LMS00 59 Methods in Drug Design: PROGRESS TEST DURATION OF PROGRESS TEST: 1 HOUR THE FOLLOWING IS PROVIDED FOR THIS EXAMINATION: ONE question paper ONE MCQ answer sheet ONE short answer book INSTRUCTIONS TO CANDIDATES: The examination paper is divided into two parts. Section A carries one half ( 50 %) of the marks. Section B carries one half ( 50 %) of the marks. Answer ALL the questions in Section A and ALL questions from Section B. Section A consists of 20 multiple choice questions Mark your answer to each question against the corresponding number on the MCQ ANSWER SHEET. For example, if you think the answer to question 12 is [C] mark your answer as follows: 12 [A] [B] [C] [D] [E]. Use an HB pencil and make your mark like this NOT a  or X or O. Erase all errors thoroughly. If you choose more than one option for a question, you will receive NO marks for that question. Mark your exam number on the answer sheet. Indicate the module title and code on the sheet. Section B consists of one short answer question. Answer the question in the answer book provided.

Section A

  1. Salicin acts as an anti-inflammatory agent in the human body. Salicin is commonly found in a. opium b. cinchona bark c. willow bark d. venoms and toxins e. microorganisms
  2. The anti- malarial drug quinine is commonly found in a. opium b. cinchona bark c. willow bark d. venoms and toxins e. microorganisms
  3. What is the term used for drugs that are similar in structure to a known drug and which are used for the same purpose? a. ‘copycat' drugs b. ‘me-too' drugs c. ‘derivative' drugs d. ‘analogue' drugs e. ‘safe’ drug
  4. There are several sources and methods of discovering new compounds. Which of the following is most likely to lead to the discovery of a complex structure quite unlike any other previously discovered? a. combinatorial chemistry b. database mining c. screening plant extracts d. me too drugs e. nuclear magnetic resonance
  5. Which of the following areas of study is not part of preclinical trials? a. Toxicology b. Drug metabolism c. Pharmacology d. Structure-activity relationships e. Determine safety and tolerance in man
  1. “ A category of compounds used in drug discovery typically characterized by having a molecular weight of less than 300 Daltons, and a logP less than 3” best describes: a. a drug-like compound b. a hit-like compound c. a fragment-like compound d. a candidate-like compound e. a lead-like compound
  2. The Andrew’s Binding Energy is a QSAR-type equation used to estimate the intrinsic binding potential of a small molecule. One of the descriptors, DOF, relates to the number of rotatable bonds in a molecule, but EXPLICITLY does not include: a. CH, terminal CH 3 and amine bonds b. OH, terminal CH 3 and amine bonds c. OH, terminal CH 3 and amide bonds d. NH, terminal CH 3 and amide bonds e. CH, terminal CH 3 and amide bonds.
  3. Which of the following SMILES strings (A-E) is valid for the molecule (Fig 1) shown below a. CC@Hc1cccc(N)c b. CC@@Hc1cccc(N)c c. CC@@Hc1ccc(N)cc d. CC@Hc1ccc(N)cc e. CC@@Hcc1ccc(N)c
  1. Which of the structures below is generated from the SMILES string: CCc1cccc(CO)c1? a. I b. II c. III d. IV e. V
  2. The chemical structures of two compounds, Molecule X and Molecule Y, were characterized using a 16-bit molecular fingerprint (see diagram below). If a Tanimoto-style similarity index was used to calculate the SIMILARITY between these two molecules, based on the fingerprints below, a value of ________ would be obtained. a. 0. b. 0. c. 0. d. 0. e. 0.
  1. Which of the following statements is CORRECT? a. The enchinocandin class of anti-fungals inhibit the synthesis of the cell wall which is composed of chitin. b. Beta lactams inhibit the synthesis of bacterial cell walls which contain chitin. c. Beta lactams inhibit the synthesis of bacterial cell walls which contain cellulose. d. The enchinocandin class of anti-fungals inhibit the synthesis of the plasma membrane which is composed of phospholipids. e. The allylamine class of anti-fungals inhibit ergosterol synthesis by blocking the transformation of lanosterol to other steroids. Section B This section is worth one half (50%) of the marks for the examination. You are advised to spend approximately 30 minutes on this section. The drug risperidone (Figure 1) is used to treat bipolar disorder, irritability in people suffering with autism and schizophrenia. Figure 1. Risperidone. i) Write down a SMILES string for risperidone. (60% of marks) ii) Using the equation given below (Figure 2), calculate the Andrew’s Binding Energy for risperidone. Does your answer indicate that risperidone is likely to bind well to its receptor? (40% of marks)

Gbinding = - 14 – (0.7 × DOF) + (0.7 × sp^2 ) + (0.8 × sp^3 ) + (11.5 × N+) + (1.2 × Nneutral)

+ (8.2 × CO 2 – ) + (10 × PO 4 - ) + (2.5 × OH) + (3.4 × C=O) + (1.1 × O/S) + (1.3 × hal)

Figure 2: Equation for calculation of Andrew’s Binding Energy