SALBUTAMOL
Salbutamol is a short-acting beta2-adrenergic receptor agonist (beta2-agonist) that is
used to treat asthma, chronic obstructive pulmonary disease (COPD), and exercise-
induced bronchospasm. It works by relaxing the muscles in the airways, making it
easier to breathe.
Mechanism of Action
Salbutamol is a beta2-agonist, which means that it binds to beta2-adrenergic
receptors in the airways. This binding activates the receptors, which then signal the
muscles in the airways to relax. This relaxation of the muscles widens the airways,
making it easier to breathe.
Classification
Salbutamol is classified as a short-acting beta2-agonist. This means that it has a
rapid onset of action and a short duration of action. Salbutamol is also a selective
beta2-agonist, which means that it has a greater affinity for beta2-adrenergic
receptors than for beta1-adrenergic receptors. This selectivity is important because
beta1-adrenergic receptors are located in the heart, and stimulation of these
receptors can cause side effects such as increased heart rate and blood pressure.
Side Effects
The most common side effects of salbutamol are tremor, nervousness, and
palpitations. Other side effects that may occur include headache, muscle cramps,
dizziness, and nausea. In rare cases, salbutamol can cause serious side effects
such as allergic reactions, seizures, and heart problems.
Dosage
The dosage of salbutamol varies depending on the patient's age, weight, and
medical condition. Salbutamol is usually taken by inhalation, but it can also be taken
orally or by injection. The usual dose of salbutamol for adults is two puffs from an
inhaler every 4 to 6 hours as needed.
Pharmacodynamics
