Docsity
Docsity

Prepare for your exams
Prepare for your exams

Study with the several resources on Docsity


Earn points to download
Earn points to download

Earn points by helping other students or get them with a premium plan


Guidelines and tips
Guidelines and tips

Regulation of Leukopoiesis: A Comprehensive Overview of Cytokines and Their Roles, Slides of Medicine

A detailed overview of the regulation of leukopoiesis, focusing on the key roles of cytokines, particularly colony stimulating factors (csfs), interleukins (ils), and tumor necrosis factors (tnf). It explores the sources, functions, and mechanisms of action of these cytokines in the development, differentiation, and activation of various leukocyte populations. The document also highlights the specific roles of different interleukins, such as il-1, il-2, il-3, il-4, il-5, and il-6, in immune cell maturation and function. Additionally, it delves into the characteristics and functions of gm-csf, g-csf, and m-csf, emphasizing their importance in granulocyte and monocyte development. Finally, the document discusses the role of tnf in inflammation and immune regulation, including its types, sources, functions, and receptor interactions.

Typology: Slides

2022/2023

Available from 11/15/2024

ankit-kumar-epj
ankit-kumar-epj 🇮🇳

6 documents

1 / 11

Toggle sidebar

This page cannot be seen from the preview

Don't miss anything!

bg1
REGULATORS OF LEUKOGENESIS
~NAME :AVIGHNA MISHRA
ROLL NO.:32
pf3
pf4
pf5
pf8
pf9
pfa

Partial preview of the text

Download Regulation of Leukopoiesis: A Comprehensive Overview of Cytokines and Their Roles and more Slides Medicine in PDF only on Docsity!

REGULATORS OF LEUKOGENESIS

~NAME :AVIGHNA MISHRA ROLL NO.:

REGULATORS OF LEUKOPOEISIS

  • (^) Leukopoiesis is regulated by cytokines specially colony stimulating factors (CSFs), Interleukins(ILs), and tumour necrosis factors(TNF).
  • (^) T lymphocytes, monocytes, fibroblast, endothelial cells, liver and kidney are the main sources of Hemopoietic Growth Factor(HGF)

SOURCES OF INTERLEUKINS

INTERLEUKIN- (IL-1) Activated macrophages INTERLEUKIN- (IL-2) T lymphocyte INTERLEUKIN- (IL-3) T lymphocyte INTERLEUKINS- (IL-4) Human mast cells, T cells INTERLEUKIN- (IL-5) Human mast cell, T cells INTERLEUKIN- (IL-6) T lymphocyte, monocyte/ macrophages, fibroblast

FUNCTIONS OF INTERLEUKINS

  • (^) IL-1, IL-6 and IL-3 promote maturation of stem cells.
  • (^) IL-5 help in the development of eosinophils hence called eosinophilic growth factor.
  • (^) IL-3&4 facilitate development of basophils.
  • (^) IL-2 inhibit myelopoiesis.

G-CSF:

  • (^) G here stands for granulocyte
  • (^) Produced by monocytes, endothelial cells and fibroblasts.
  • (^) Helps in development and function of granulocytes.  M-CSF:
  • (^) M here stands for Monocytes
  • (^) Produced by variety of cells, including endothelial cells, fibroblasts, osteoblasts, smooth muscle and macrophages,
  • (^) Also called CSF-
  • (^) Promotes proliferation of monocytes and macrophages and also stimulates fuctions of monocytes.

TUMOUR NECROSIS FACTOR (TNF)

  • (^) TNF is a cytokine involved in the regulation of immune cells and inflammation.
  • (^) Types: Two main types: TNF-alpha and TNF-beta. TNF-alpha is more widely studied and clinically significant.
  • (^) Receptors:
    • Binds to TNF receptors (TNFR1 and TNFR2) on cell

membranes, triggering downstream signaling pathways.