CROSSTALK BETWEEN REACTIVE OXYGEN
SPECIES AND PRO-INFLAMMATORY MARKERS IN
DEVELOPING VARIOUS CHRONIC DISEASES
Mukund Jha
Email id- jhamukund508@gmail.com
Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research
Jamia Hamdard, Hamdard Nagar, New Delhi-62
Introduction
Inflammation work as defense and healing process against tissue damage with customary marks as
redness, pain, heat and swelling.
A currently acceptable hypothesis is that the relationship between ROS and pro-inflammatory markers is
directly interactive.
The more ROS produce, the more pro-inflammatory markers produce. Meanwhile, a considerable body of
experimental evidence has shown that ROS activate NFκB, which results in the transcriptional activation
of genes relevant for pro-inflammation.
Reactive oxygen species and pro-inflammatory markers
Diseases associated with ROS and Pro-inflammatory markers
Discussion
Persistent production of ROS and pro-
inflammatory markers is associated with each
other. It is worth to mention that patients with
cancer, atherosclerosis, and arthritis could be
essentially good candidates for novel anti-
inflammatory and antioxidant therapy.
Overproduction of ROS triggers the pro-
inflammatory process through activation of several
regulatory proteins in the tissue. ROS production
level must be reduce to limit various chronic
diseases.
Conclusion
Refrence
Yazan Ranneh . Faisal Ali . Abdah Md Akim . Hasiah Abd.
Hamid . Huzwah Khazaai . Abdulmannan Fadel- review (2017)
on same subject
Signaling activation
NFκB
STAT3
Inflammation-related cancer
Chemokines Prostaglandin(C0X2)
Cytokines Inflammasome
Tumorigenesis
Tissue invasion
DNA mutation
Evasion of apostosis
Atherosclerosis Cancer
ROS
Mitochondria
NADPH oxidase
ROS regulate kinases
,transcription and
cytokines(e.g-COX-2,
IL-6, IL-1, TNF-a) which
are synthesized as result
of NF- κB mediation.
Nuclear factor-kappa B
(NF- κB) has a potent
role in regulating the
pro-inflammatory gene
expression.
Arthritis
