Pharmacology of drugs acting on uterus, Slides of Pharmacology

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COURSE TITLE:

pharmacology of drugs

acting on uterus

COURSE CODE:

BP503T

Name of university

INDIRA GANDHI NATIONAL UNIVERSITY ,

AMARKANTAK, M.P , INDIA - 484887

DEPARTMENT WITH SUBJECT DEPARTMENT OF PHARMACY ( PHARMACOLOGY)

CONCERNED TEACHERS SIGNATURE

STUDENT’ SIGNATURE shivam aditya

DATE OF SUBMISSION SEPTEMBER 11, 2022

MARKS OBTAINED:

CONTENTS

1. ACKNOWLEDGEMENT

2. CERTIFICATE

3. INTRODUCTIONS

4. BACKGROUND

5. SYNTHESIS AND SECRETION OF OXYTOCIN

6. OXYTOCIN AS LOVE HORMONE

7. ROLE AND FUNCTION OF OXYTOCIN

8. PHASES OF LABOUR

9. MECHANISMS OF NORMAL LABOUR

10. ABNORMAL LABOUR: MALPOSITION AND MALPRESENTATION

11. Drug action

12. KEYWORDS

13. CONCLUSION AND REFERENCES

Certificate

The assignment entered here is satisfactorily performed by Master

/MissSHIVAM ADITYAstudying in INDIRA GANDHI NATIONAL

TRIBAL UNIVERSITY, AMARKANTAK course

BPHARMA CYs emester5th

Enrollment no -2001109049 during the academic year 2022-

Teachers signature……………………………………. Examiner signature…………………………

Principal / HOD…………………………………………..

Date : SEPTEMBER 11, 2022

INTRODUCTION

Uterus is one most important part of female reproductive system

. Uterus is concerned with regular menstrual flow and child

bearing capacity for female through which every women has to

go through.

As far as concerned with pharmacology the drugs acting on

uterus affects both endometrium and myometrium.

Myometrium receive both sympathetic and parasympathetic

innervation.

The response shown by myometrium towards drugs is affected

by both hormonal and gestational status.

OXYTOCIN: SYNTHESIS AND SECRETION

● Oxytocin is polypeptide hormone which is

synthesized in supraoptic and paraventricular

nuclei of hypothalamus and it is transported to

posterior pituitary with help of axonal part

present in it.

● It is released during parturition and nipple

stimulation.

OXYTOCIN AS A LOVE HORMONE: WHY?

Oxytocin is said to be love hormone , because of it affinity towards the bonding in

individuals. Though they are various ideas that can be presumed but some textual

formats recognized it as the hormone of affectionate love. There is far difference

between perfectionate love and affectionate love. Unless or until situation of love

arousement is there this a perfectationate love with is developed by

neurotransmitters serotonin and dopamine but the affinity towards the opposite

gender till the baby planning and gestation is affectionate love which is mediated

by oxytocin.

Not only that even after parturition oxytocin produces in such amount that baby is

recognized by mother very quickly.

Some text said that when you in tension or having upset mind , just have a touch

with mothers body or just talk from mother on phone call if you are far away , this

touchwood triggers oxytocin amount in your body and it will releases the tension.

Stages of labour DESCRIPTION^ CHARACTERISTIC S

DURATION IN

PRIMIGRAVIDA

DURATION IN

MULTIGRAVIDA

STAGE:1 Starts with onset of true labor pain and ends with full dilation of cervix

● Latent phase ● Active phase It consist of fallowing : acceleration , phase of maximum slope and deceleration phase

● 8-20 hrs ● 6-12 hrs

● 6-14 hrs ● 3-6 hrs

STAGE:2 Starts from full dilation of cervix and end with expulsion of foetus from birth canal

● 1-2 hrs ● 30min to 1hr

STAGE:3 Starts from explusion of foetus and end explusion of placenta and membrane

● 15min ● 15min

STAGE:4 Stages of observation: start from expulsion placenta upto 1 hr after explusion of placenta.

● 60min ● 60 min

ABNORMAL LABOUR: MALPOSITION AND

MALPRESENTATION

1. Malposition and malpresentation are common causes of abnormal risk

of labour and are associated with increased risk of maternal or fetal

complications.

● Malposition: position such as occipitoanterior or occipitotransverse

position is called malposition.

● Malpresentation: any presentation of the foetus other than the vertex

presentation is termed as malpresentation. Brow , face , breech and

transverse lie are included in this.

BREECH

PRESENTATION

TRANSVERSE

LIE POSITION

CLASSIFICATION:

Posterior pituitary hormones

ERGOT

ALKALOIDS

PROSTAGLANDIN

S ANALOGUES

MISCELLANEOUS

Oxytocin Ergometrine Dinoprostone Dinoprost

Ethacridine

Desamino Oxytocin

Methylergometrine Carboprost Quinine

Misoprostol + mifepristone