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PuaRMACEUTICS SEMI SOLID DOSAGE FORH— Suppositories — Susp oni foties arr Actid dotoy fobon 4 medicament for Jmsation dnto bedy canities other than rout. he: uan be Unerted sto Aechum , vagina OH horol —> The meolicemet ds uUncotportel unto the Auppesitory base dnd the product will ether mult A clisdolar dan the badly conitt [eid to Arlease the medi Cemenk- (iy These Can be adminnted ta potienls wha cannot Avsotleuw the oly casi by . Uiy These exert a aiect 1 Aabid action un Huguet qeng Hough bhood StAtam. Ginn These One dngerttal dito Atetion to promote. Wvacuntitn of Hye bowel. Thee au unit olosage form Y Mgt dv) Pane>4 (VW) These arr Coweniet moodle o Adminis tastion 9 olugs Usich Urritote gastro - tnkestinel Track . Dis advankag es —> Go The dmitant oliags Camt be aotminiateud by thes Wy The Auppentories an Agpited to be stork ot Lew Lemnb ratiae . iv they OAL Mer Expenmee thm Johlets. Uv) Thy Camnet be prapaud earily. Ty pea ¢ Ssppo sito ries 0) Rectal SArppositou es — « these ake meat fr troduction, into the Atelivn for their Sup tonic eft: » Thee ar made rem Heobroma el dyol ar Cre — dgble dn Various Altes Lo meet the heeela a alk ape - Cares weight I-2 4 » Shape — Cone or torpelo Shobed . 1 eg.m Sealatives , Analg ears, etc. PAnE> 2 ® Ear Cones — clio knew, ay Aurinaria «Thee ae ment fe Untho duction date the tar and OAR Ulead Aare. » They Qn wtptially pachauel with Eheobroma oil + Shape — tin, Lang dnd ylindi cal Shapeol P Weight > La ram. r Supp asitony Bowe he the exci bie tohiel are Wied du the Wan my] tree —> They ar the bay on bat of up poai tom eo dnd plow a icp orton Aol tn- . hasirched wing Abope Oral pels! Atete > Aukpoxi tou'es . dn the Acam 4 mebiumerk - © Gt shoulel metk at beady Lepastns ak disso or daperoe don looaly pucisls. . @ Jt Ahoulal keep Gh Ahspe shin being Aen. ® Ik Ahowtsl Kilian tne preoli Comert Atastily @ 9k Abotsl be parr toxic And hor- iritent te the mucous nwoml.pur - Page> 4 © Jt Ahoutd be stable on Array © Jt Ahewtel be Compatible with Lamy humber ef rugs. Ook arava ne eal weed and uk About pot adhe to the mews Clauifietion of Suppository Baoea : 1. Fatty Baves - iy Theobroma ol C Coma baker) — 4 wa y blew st, whut Aclid obteine fom Crush eal And Aasstesl Seeds of thobsewn Colea. > bt As a butt Like consistenes Asusing melbing boik 40-35. — Jt wy a rexdu of Py cork nts stearic, Otic , palm - ite and ath fates acids « oy Oto ds Lonvideud o mort Auitable ban for ActaL Aulb om tories bout. hot suiteble Jor pewaries « Ral wil Ly Aeafe out ef Ube cavities Anal alte immisdble voi th mucom Acouh ov: PAGE? S 2. Wate Soluble and Wot NUscible Bases t- cD) Gly cero ~ 9 elatfn base — > JE ds & mixture ty cou! ne and water whic Ws meaolt Abi} ba the addition Yf gelotin. —s The bare may be used for prrpari alt type Aubbaaitoies bak dk da portioalon cased bos ae berares. —> Thue barn an Havbuent ,; hich Lud te dimes 1 Auer prpprual oo fot elds —> Thu bar We well suite for Aupp oritorics Corkainirng boric acid , chlotal Ayolake, brsmictes , ocices , 1ocdeform, Opium ett. —> Disoduackage - The Ww inempatilele wsith mars clays denice chur , gaslic aerd eb. _ Prwewobiva an Arpad du te bactetal dnd motel grows eTheae ban an Awbic Ord Ayia Apectal ve Aeypaachic Abecial Abouye Auch od tannic deid, Pace F (iy Soop - Hy cain base — belts wa Arplocral ba either Curd Aoxb OO Locum, ¢ lea Aste bo mete Aare anal good qwolify of Aubporiteies. —> The win clin adu ankage of Hum baw we Auyao scopic hatir wud muat be pbroteteal Th waxed paper or bth fr. Gh) Poly cthylerr a'y cols Olan Frou ao Carbo woaxey/ boty gycols/ 2 The manrogets ening motel wright lus then 1906 one Liquicls and thor with mrodicalar Weight Agher Han 18909 car Wax Like Atel. — Advantages ~ + The clo net allow the bacterial 1 mel grcoth. F Phapicot pAcb ecties of the bare Can be Chow ed aecotclindy . q thy browicle prolong eal achip, du to slow Oa dining hot . » They olo hot stich te Aide 4 hmoulols . — 5 Disadvatayes — » They orn Agpoarepic tn heture The aur wcgmpalible with cetedin omg Like tenrnine, pHfenels te. PAGE 8 Preparation of Sup p oaitories © Rolling Metho of * > Jt Us an amdiadt Muthed of pAcp axing the App oi berics. —> The method ws prot ued Nowadays. @ Coll corprausion Method = Hewo labile and dnsolble dra fr bore Lith medi Ca- —> Jt us uses because heating anel Atiaing Of ment ws bek Atyued. —s The various steps invelual th this im theal — ‘ Fimdy nix all Tngarciats usith Aapporitery, bar and huke fine Powder: | «Now dllel Hy man Ph pinche and ob bly dobai cont Tw He Wwowd » On Lombrunin , Auh|pon ito man aul into meortd aul get Mhsbed , Hun beke out and packeol . PAME= 10 @ Hot process or fusion method! * > IE we commands untes den the pArpation of Aubpo~ Aiton fu alls Parsing pap ores. — The Auppesitoy bare is melted, the predicament as MLorporwted Py ck anal filled in Lebaicotel pould . —> O Cooling» Aupporitoues ar formed urhich aL Atmeved from the Avdpesitory moots. = Sep oti borg mew) — +m dtabensing , the Auppesitmg meld shaming 6-12 Cami, usit, oltsircd Abbe and Aire wy be umed . © The moulds an genemly Koel rp of Ateainies AHN, Widcel- Copper abbey , bra , aluminium or partic. —> Lubichen a) wrouwks| — » the LnbricHen 8) He At pasion moll Us eAental Pr com Cotea bitty a“ Sy cero - g Ltn bose Uy Used fou Hepa parathion of Poop oni hoe. : S.No. Name of the Rave LubAteamt ur ed 4. Caton buttr. Soft Soap 10g Gl ced 104 Alcohol Jor]. sort 2. (ly terw ~ geen Liquid parsthin ov Arachis oil. 3. Emulditying Rave No Libri cat ta Wel fAGE = 1) ® Gledation of He amount oY theobrona ot duploud by ol gramme af pmesli (gmnent = CO~C) Grtmme of a-c » Dis place eck volue of mreali comet = —> Method 4 Prrporakion — © Clem, dey ous Jubrlcant mould with Lged Porryfin or Qnchariy vil Amd puk wn Agni gusts @ Hex suppository base fe loore dm a Napowtion dish and add ak Im Aoakrd rmrcesd M4 exerpiet , sti ant bok at ew water bal, for |S privates or Lnbel aglakin ds complete @ Dishewe medicament] lnys in the clear Actutio of bare Ons pour th At hears With coubtast Abiming te the chilled 0) W Asp tat, Ast positow Jn & Wares| b (eu pork H pnsol box. PAGES 13. Evaluation 4 Supbositorics © Appearance tet _—. Supp sritedies mut Aas Srevoth surface nifehen Ahape And alorcemr Of Chacte . : @ Weight variation — for Ho, She amnaye weight of ut . dy ermrr Uniforr doe | each duppo- Ai tow @ Melting Rowson thy mut be mett ot body Minp eran fer the, but rubpasitoices tn water batt, for ZO wn. ot 37°C. G Disinty ratio tut- tut how fut the rupporitey braks dow, tn body Lrke Covtiting » Fo Hay, put Avbfporitedas in olislteyahion ofparctes Leith Auttable Wredum and cheete then Hea sf oli elation. © Se eterng [Banjos His, we Lae to menue ime In totik, oS Ejies, hey, pobbeuiog gee PAGE 14 
