Basics of Pediatric Oncology
docsity.com
Prepare for your exams
Study with the several resources on Docsity
Earn points to download
Earn points by helping other students or get them with a premium plan
Guidelines and tips
Prepare for your exams
Study with the several resources on Docsity
Earn points to download
Earn points by helping other students or get them with a premium plan
Community
Ask the community
Ask the community for help and clear up your study doubts
University Rankings
Discover the best universities in your country according to Docsity users
Free resources
Our save-the-student-ebooks!
Download our free guides on studying techniques, anxiety management strategies, and thesis advice from Docsity tutors
Pediatric Oncology - Pediatric - Lecture Slides, Slides of Pediatrics
Complete lecture series on Pediatrics is available on docity. You can read online and download it for free. This lecture keywords are: Pediatric Oncology, Epidemiology of Pediatric Oncology, Chemotherapy Principles, Pediatric Malignancy, Predisposing Factors, Hereditary, Unique Aspects of Pediatric Oncology, Chemotherapy and Radiation Therapy, Development and Cns Function, Reproductive Function
Typology: Slides
2012/2013
1 / 23
This page cannot be seen from the preview
Don't miss anything!
Related documents
Partial preview of the text
Download Pediatric Oncology - Pediatric - Lecture Slides and more Slides Pediatrics in PDF only on Docsity!
Basics of Pediatric Oncology
Objectives
Review epidemiology of pediatric oncology
Discuss unique aspects of pediatric oncology
treatment
Discuss general chemotherapy principles in
pediatric oncology
BRIEF review of the most common pediatric
malignancies
Cancer Treatment in US
>90% of children diagnosed with cancer
are seen and treated at a COG affiliated institute
Overall Survival is > 65% in the United
States
Predisposing Factors
Genetic
- Syndromes (trisomy 21), bone marrow
failure
Hereditary
- Wilms Tumor, Retinoblastoma
Environmental
- Radiation, toxins
Trends in age-adjusted incidence rates for all childhood cancers by sex, age <20 all races combined
Year of Diagnosis SEER, NCI 1995
Age-adjusted incidence rates for childhood cancer by ICCC groups, age <20 all races, both sexes, SEER, 1975-
Average annual rate per million (^) SEER, NCI 1995
SEER, NCI 1995
Age Specific Incidence rates for childhood cancer by ICCC group, all races, both sexes
Age at Diagnosis
SEER, NCI 1995
Age at Diagnosis
Age Specific Incidence rates for childhood cancer by ICCC group, all races, both sexes
Distribution of Cancer types, ages 15-19, all races, both sexes
SEER, NCI 1995
Distribution of Cancer types, ages <5, all races, both sexes
Age Association with Specific
Malignancies
Classically peak incidence of leukemias,
CNS, Wilms and Neuroblastoma in younger age group
Lymphomas and bone tumors in older
age group
Unique Aspects of Pediatric
Oncology
Long Term Survivors
- Second Malignancies
- Chemotherapy and radiation therapy
- Development and CNS function
- Cardiac, Renal, and Pulmonary Toxicity
- Reproductive Function
Unusual Aspects of Pediatric
Malignancy
In general these are rare compared to
adult malignancy
Venous access issues usually more
difficult compared to adults
Psychosocial aspects of treatment
General Principles of Cancer
Treatment
Systemic Therapy
- Chemotherapy
- Leukemias
- For solid tumors known to have risk for recurrence/metastasis
- BMT
General Principles of
Chemotherapy
Addition of chemotherapy (1950s) has
improved prognosis dramatically
Chemotherapy can be used as primary
therapy and as adjuvant therapy
Combination Chemotherapy has been
shown to be essential, especially in ALL
- Single drug induces remission in 65% of