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Medicinal Chemistry III: Examination Questions and Answers for B. Pharmacy Degree, Exams of Pharmaceutical Chemistry

The Tamil Nadu Dr. M.G.R. Medical UniversityPharmaceutical Chemistry

A comprehensive set of examination questions and answers for the medicinal chemistry iii course, designed for b. Pharmacy students. It covers a wide range of topics, including anti-tubercular agents, combinatorial chemistry, anti-viral agents, beta-lactamase inhibitors, drug design, and more. The questions are structured in a way that encourages critical thinking and deeper analysis of the subject matter. A valuable resource for students preparing for their medicinal chemistry iii exams.

Typology: Exams

2023/2024

Uploaded on 11/10/2024

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murugan-pratheepa 🇮🇳

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THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY
[BPHARM 0321] MARCH 2021 Sub. Code: 2059
(SEPTEMBER 2020 EXAM SESSION)
B. PHARMACY DEGREE EXAMINATION
PCI Regulation SEMESTER  VI
PAPER I – MEDICINAL CHEMISTRY III
Q.P. Code : 562059
Time: Three hours Maximum: 75 Marks
I. Elaborate on: Answer any TWO questions. (2 x 10 = 20)
1. Define Tuberculosis and Anti- tubercular agents. Write about synthesis, mechanism
of action of Isoniazid and para amino salicylic acid.
2. Write about Solid phase synthesis and applications of combinatorial chemistry.
3. Write the nomenclature, classification and Structure activity relationship of
Tetracycline.
II. Write notes on: Answer any SEVEN questions. (7 x 5 = 35)
1. Classification of anti – viral agents.
2. Write a short note on Beta lactamase inhibitors.
3. Discuss about various approaches used in drug design.
4. Write about synthesis of Trimethoprim and Dapsone.
5. Write a note on Macrolide antibiotics.
6. Basic concepts of prodrug design.
7. Write about synthesis of Miconazole and Tolnaftate.
8. Write the structures for the following: a). Metronidazole b). Chloroquine
c). Cotrimoxazole d). Chlorobutanol e). Hexamine
9. Write a short note on Taft’s steric parameter.
III. Short answers on: Answer ALL questions. (10 x 2 = 20)
1. Define partition coefficient.
2. Molecular docking.
3. Write the structure and use of Methanamine.
4. Write the structure of Amantadine Hcl.
5. Define Anthelmintics.
6. Pharmacophore modeling.
7. Antifungal agents.
8. Combinatorial chemistry.
9. Structure and uses of Quinine sulphate.
10.Mechanism of action of Erythromycin.
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Download Medicinal Chemistry III: Examination Questions and Answers for B. Pharmacy Degree and more Exams Pharmaceutical Chemistry in PDF only on Docsity!

THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY

[BPHARM 0321] MARCH 2021 Sub. Code: 2059 (SEPTEMBER 2020 EXAM SESSION) B. PHARMACY DEGREE EXAMINATION PCI Regulation SEMESTER  VI PAPER I – MEDICINAL CHEMISTRY III Q.P. Code : 562059 Time: Three hours Maximum: 75 Marks I. Elaborate on: Answer any TWO questions. (2 x 10 = 20)

  1. Define Tuberculosis and Anti- tubercular agents. Write about synthesis, mechanism of action of Isoniazid and para amino salicylic acid.
  2. Write about Solid phase synthesis and applications of combinatorial chemistry.
  3. Write the nomenclature, classification and Structure activity relationship of Tetracycline. II. Write notes on: Answer any SEVEN questions. (7 x 5 = 35)
  4. Classification of anti – viral agents.
  5. Write a short note on Beta lactamase inhibitors.
  6. Discuss about various approaches used in drug design.
  7. Write about synthesis of Trimethoprim and Dapsone.
  8. Write a note on Macrolide antibiotics.
  9. Basic concepts of prodrug design.
  10. Write about synthesis of Miconazole and Tolnaftate.
  11. Write the structures for the following: a). Metronidazole b). Chloroquine c). Cotrimoxazole d). Chlorobutanol e). Hexamine
  12. Write a short note on Taft’s steric parameter. III. Short answers on: Answer ALL questions. (10 x 2 = 20)
  13. Define partition coefficient.
  14. Molecular docking.
  15. Write the structure and use of Methanamine.
  16. Write the structure of Amantadine Hcl.
  17. Define Anthelmintics.
  18. Pharmacophore modeling.
  19. Antifungal agents.
  20. Combinatorial chemistry.
  21. Structure and uses of Quinine sulphate.
  22. Mechanism of action of Erythromycin.

THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY

[BPHARM 0921] SEPTEMBER 2021 Sub. Code: 2059 (SEPTEMBER 2020 EXAM SESSION) B. PHARMACY DEGREE EXAMINATION PCI Regulation 2017 - SEMESTER - VI PAPER I – MEDICINAL CHEMISTRY III Q.P. Code : 562059 Time: Three hours Maximum: 75 Marks I. Elaborate on: Answer any TWO questions. (2 x 10 = 20)

  1. Discuss briefly about chemistry, classification and SAR of Sulfonamides.
  2. Write about the physico-chemical parameters used in Quantitative Structure Activity Relationship (QSAR) studies.
  3. Write about the nomenclature, classification and degradation of penicillin. II. Write notes on: Answer any SEVEN questions. (7 x 5 = 35)
  4. Write a note on pharmacophore modeling.
  5. Discuss about Structure activity relationship of Quinolones.
  6. Write about synthesis and uses of Chloramphenicol.
  7. Define and classify drugs used for Urinary tract infection (UTI).
  8. Write the structures for the following : a). Ketoconazole b). Acyclovir c). Pyrazinamide d). Thiabendazole e). Sulfamethoxazole.
  9. Write a note on Aminoglycosides.
  10. Write the synthesis, mechanism of action and uses of Sulfacetamide.
  11. Write a note on Anti – malarial drugs.
  12. Write the application of prodrug. III. Short answers on: Answer ALL questions. (10 x 2 = 20)
  13. Write the synthesis of nitrofurantoin.
  14. What is molecular docking?
  15. Write a note on Monobactams.
  16. What are beta lactamase inhibitors?
  17. Write the structure and uses of Cycloserine.
  18. Write the uses of Nalidixic acid and Clotrimazole.
  19. Write the synthesis of Diethyl carbamazepine citrate.
  20. Define partition coefficient.
  21. Write the structure and uses of para amino salicylic acid.
  22. Define anthelmintics with examples.

[BPHARM 0522] MAY 2022 Sub. Code: 2059 (SEPTEMBER 2021 EXAM SESSION) B. PHARMACY DEGREE EXAMINATION PCI Regulation SEMESTER - VI PAPER I – MEDICINAL CHEMISTRY III Q.P. Code : 562059 Time: Three hours Maximum: 75 Marks I. Elaborate on: Answer any TWO questions. (2 x 10 = 20)

  1. Discuss the chemistry, mechanism of action, SAR and synthesis of Chloramphenicol.
  2. Classify sulphonamides. Briefly discuss the mechanism of action and SAR of sulphonamides. Enumerate the synthesis of sulfacetamide.
  3. Write a brief account on lipophilic parameters and electronic descriptors involved in QSAR. II. Write notes on: Answer any SEVEN questions. (7 x 5 = 35)
  4. Classify quinolone urinary tract anti-infectives and write the structure and MOA of any two flouro quinolones.
  5. Describe briefly on various approaches of prodrug design.
  6. Give a note on Azole antifungals.
  7. Describe the structure and mechanism of action of Metronidazole and Tinidazole.
  8. Write a short note on β-lactamase inhibitors.
  9. Write the structure and uses of Mebendazole and Diethylcarbamate citrate
  10. Write the mechanism of action and SAR of aminoglycosides.
  11. Synthesis of pamaquine.
  12. Write the classification and SAR of penicillin antibiotics. III. Short answers on: Answer ALL questions. (10 x 2 = 20)
  13. MOA of tetracyclines.
  14. Structure and uses of Rifampicin.
  15. Monobactam antibiotics.
  16. Structure of any two cephalosporins.
  17. Classify antiprotozoal agents.
  18. Nalidixic acid.
  19. Write benzimidazole anthelmintics.
  20. Any two β-lactamase resistant penicillins.
  21. HIV Protease inhibitors.
  22. Define Combinatorial Chemistry along with any two applications?

[BPHARM 1022] OCTOBER 2022 Sub. Code: 2059 (MARCH 2022 EXAM SESSION) B.PHARMACY DEGREE COURSE (SEMESTER EXAMINATIONS) PCI Regulation 2017 – SEMESTER VI PAPER I – MEDICINAL CHEMISTRY III Q.P. Code : 562059 Time: Three hours Maximum: 75 Marks I. Elaborate on: Answer any TWO questions. (2 x 10 = 20)

  1. Explain combinatorial chemistry in detail.
  2. Briefly discuss the mechanism of action and SAR of azole antifungals.
  3. Define and classify urinary-tract Anti-infective agents with examples. Explain the chemistry, SAR, mechanism of action of Quinolone anti-bacterial agents. II. Write notes on: Answer any SEVEN questions. (7 x 5 = 35)
  4. Explain the mechanism of action of Metronidazole.
  5. Describe the mechanism of action of (a) Polyene antifungals (b) Allylamine antifungals.
  6. Write the mechanism of action and structure of any one class of antitubercular agents.
  7. Discuss the mechanism of action, SAR and synthesis of chloramphenicol.
  8. Describe various electronic parameters involved in QSAR study.
  9. Write notes on synergism and mechanism of action of sulphonamide.
  10. Brief out the chemistry of cephalosporins.
  11. Outline the synthesis of Chloroquine.
  12. Write the structure of a) trimethoprim b) pyrimethamine. III. Short answers on: Answer ALL questions. (10 x 2 = 20)
  13. Write the structure and use of mebendazole.
  14. Give an account on bigaunaide antimalarials.
  15. Write the structure of sulfonamides used for burn therapy.
  16. Give an account on saquinavir.
  17. Write a note on the applications of combinatorial library synthesis.
  18. Write a note on β- Lactamase inhibitors.
  19. Define amoebiasis and give an account on the causative agents.
  20. Write the synthesis of amantadine.
  21. Brief out on the types of prodrugs.
  22. Classify macrolides with examples.

[B.PHARM 0823] AUGUST 2023 Sub. Code: 2059 (MARCH 2023 EXAM SESSION) B.PHARMACY DEGREE COURSE (SEMESTER EXAMINATIONS) PCI Regulation 2017 – SEMESTER VI PAPER I – MEDICINAL CHEMISTRY III Q.P. Code: 562059 Time: Three hours Maximum: 75 Marks I. Elaborate on: Answer any TWO questions. (2 x 10 = 20)

  1. Classify antibiotics. Explain in detail about the chemistry and SAR of cephalosporins.
  2. Write down the Synthesis and Mechanism of Chloroquine. Add a note on SAR of 4- Amino quinolines.
  3. Write the classification of Anti-viral drugs with suitable examples. Explain the synthesis and mechanism of Acyclovir. II. Write notes on: Answer any SEVEN questions. (7 x 5 = 35)
  4. Write a note on Combinatorial Chemistry.
  5. Write the structure and uses of clotrimazole and Tolnaftate.
  6. Give the structure and uses of: a) Tetracycline b) Erythromycin
  7. Write short notes on anthelmintics.
  8. Write a note on partition coefficient and Hammet’s electronic parameter.
  9. Synthesis of Metronidazole.
  10. Anti tubercular antibiotics.
  11. Write the structure, Mechanism of action and uses of sulphacetamide sodium and sulphasalazine.
  12. Write the chemistry, Mechanism of action and uses of Amphotericin B. III. Short answers on: Answer ALL questions. (10 x 2 = 20)
  13. Structure and mode of action of Ethionamide.
  14. Mechanism of action of Sulphonamides.
  15. Mechanism of ciprofloxacin.
  16. Write the name of any two folate reductase inhibitors.
  17. Write about Pharmacophore modeling.
  18. Write mechanism of β lactam antibiotics.
  19. Write structure and uses of Griseofulvin and Fluconazole.
  20. Artemesinin antimalarials.
  21. Sulphapyridine.
  22. MOA of Chloramphenicol.

[B.PHARM 1223] DECEMBER 2023 Sub. Code: 2059 (SEPTEMBER 2023 EXAM SESSION) B.PHARMACY DEGREE COURSE (SEMESTER EXAMINATIONS) PCI Regulation 2017 – SEMESTER VI PAPER I – MEDICINAL CHEMISTRY III Q.P. Code: 562059 Time: Three hours Maximum: 75 Marks I. Elaborate on: Answer any TWO questions. (2 x 10 = 20)

  1. Write the structure, mechanism and SAR of Tetracyclines.
  2. Define and classify anti-tubercular agents. Give the synthesis and mechanism of action of following drugs. a. Isoniazid. b. Para amino salicylic acid.
  3. Explain various approaches of drug design. II. Write notes on: Answer any SEVEN questions. (7 x 5 = 35)
  4. Describe the structure and mechanism of action of Polyene antifungal antibiotics.
  5. Write the structure and uses of Streptomycin and Kanamycin.
  6. Write the structure, mechanism of action and uses of Quinacrine and Pamaquine.
  7. Synthesis of Mebendazole.
  8. Classify and give the structure and uses of Reverse Transcriptase (RT) inhibitors.
  9. Write a short note on anti protozoals.
  10. Synthesis of Sulphamethoxazole.
  11. Structure and uses of Azithromycin and Clindamycin.
  12. Write short notes on SAR of Quinolone antibacterials. III. Short answers on: Answer ALL questions. (10 x 2 = 20)
  13. Trimethoprim.
  14. Structure and uses of dapsone.
  15. Cycloserine.
  16. Structure and uses of Norfloxacin.
  17. Structure and uses of Naftifine HCl.
  18. Primaquine.
  19. Structure and uses of didanosine.
  20. MOA of penicillin.
  21. Define prodrug with example.
  22. Write the structure of ciprofloxacin and nitrofurantoin.