Introduction to Virology
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Introduction to Virology - Virology - Lecture Slides, Slides of Virology
Introduction to Virology, Viral Diseases, Important Viruses, Arboviral Encephalitis, Louisiana, Modes of Virus Transmission, Controlling Virus, Blood and Body Fluids, Prophylaxis are the important key points of lecture slides of Virology.
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2012/2013
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Introduction to Virology
Viral Diseases
Arboviral Encephalitis
in Louisiana
- Respiratory
- Fecal-Oral
- Contact (fomites, lesions, saliva)
- Zoonoses (insects and animals)
- Blood
- Sexual
- Materal-Neonatal
MODES OF VIRUS
TRANSMISSION
Viral Classification, Structure
and Replication
Cellular Level
WHAT IS A VIRUS?
“ filterable agents”
Obligate intracellular parasites
RNA or DNA genome
PARVOVIRUS SS linear PAPOVAVIRUS DS, circular ADENOVIRUS DS, linear HERPESVIRUS DS, linear POXVIRUS DS, linear
HEPADNAVIRUS DS, circular
DNA VIRUSES GENOME
PICORNAVIRUSES SS + CALICIVIRUS SS + REOVIRUS DS (+/-) TOGAVIRUS SS + FLAVIVIRUS SS + RHABDOVIRUS SS - PARAMYXOVIRUS SS - ORTHOMYXOVIRUS SS - RETROVIRUS SS + (two identical) FILOVIRUS SS - ARENAVIRUS SS - BUNYAVIRUS SS - CORONAVIRUS SS +
RNA VIRUSES GENOME
Virion – the complete virus particle
Capsid – the protein coat surrounding the nucleic acid genome
Capsomers – the repeating protein subunits that make up the capsid Protomers – the polypeptide chains which make up the capsomers
Symmetry – The viral capsid is assembled from individual proteins. The arrangement of the capsid around its viral genetic material is unique for each type of virus. The general properties of this arrangement define the shape and symmetry.
The simplest structures that can be built are helical and icosahedral.
VIRAL ATTACHMENT &
ENTRY
Mechanisms of Viral
Pathogenesis
Inhibition of cellular protein synthesis
Polioviruses, herpes simplex, poxviruses, toagaviruses
Inhibition/degradation of DNA Herpesviruses
Syncytia (^) varicella zoster, paramyxovirusesHerpes simplex, HIV,
Inclusion Bodies (^) Poxvirus, Reovirus, CMVRabies, Adenovirus,
Mechanisms of Viral Cytopathogenesis
- Syncytia – a mass of cytoplasm
containing several nuclei. The expression of cell surface glycoproteins of some viruses like HIV, herpesviruses and Respiratory Syncytial Virus (a paramyxoviruse) can trigger the fusion of neighboring cells into multinucleated giant cells called syncytia.