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An in-depth exploration of various aspects of glomerular diseases, including clinical presentations, pathology, etiology, and specific cases. Topics covered include nephritis, urine analysis, glomerular proliferation, immunologic injury, and etiology of glomerular diseases. The document also includes real-life patient cases and discussions on acute nephritic syndrome, post-streptococcal GN, serum complement levels, demographics of IgA nephropathy, and Henoch-Schönlein Purpura.
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Vivette D’Agati Jai Radhakrishnan
Nephritis Renal failure Hypertension Hematuria A t
Nephrotic Syndrome Heavy Proteinuria Low serum Albumin Edema
Asymptomatic Urinary Abnormalities
High serum lipids
Urinary RBC’s, sometimes deformed RBC Casts
Large amounts Albuminuria ( >3g/Day )
Proliferation or Sclerosis Distribution
2 2. ExtracapillaryExtracapillary (crescentic)
2 Segmental2. Segmental VsVs GlobalGlobal
20 20-25% of cardiac output 2 % f di
High glomerular capillary pressure
Fenestrated endothelium
Concentration (sieving effect)
HistoryHistory Primary Glomerular Physical Exam Laboratory, Radiological tests
Primary Glomerular Disease
