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EBIO 1210 Exam 4 Latest Updated Exam Study Guide 2025/2026
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Combinations of alleles that are non-parental are called.... - ansRecombinant Genes located on the same chromosome that tend to be inherited together are called.... - ansLinked genes What is the advantage of doing a test cross vs. an F1xF1 cross? - ansWe know the patterns of heredity We can isolate what is actually going on What is the mechanism for recombining alleles? - ansCrossing over in Meiosis I Genetic map of a chromosome based on recombination frequencies - ansLinkage Map One map unit = ____% recombination frequency - ans1% Independent assortment does NOT (always) apply to genes on the same chromosome. Why not? A. Allele combinations on a chromosome can never be broken up B. A combination of alleles on one chromosome is less likely to be broken up than a combination of alleles from multiple chromosomes C. Non-homologous chromosomes pair up during meiosis D. Meiosis makes it impossible to create non-parental combinations of alleles in gametes. - ansB. A combination of alleles on one chromosome is less likely to be broken up than a combination of alleles from multiple chromosomes Why would some genes be inherited neither completely together nor completely independently? - ansRecombination of linked genes Suppose we are investigating two characters (e.g.,body color and wing type) in a study of heredity. If the ratio in the offspring of parental types : recombinant types is intermediate between the predictions of dependent assortment and independent assortment, then we should conclude that: A. meiosis has been disrupted in the parents used to produce the observed offspring B. the parents used to produce the offspring have cancer C. Mendel's law of segregation has been violated D. This outcome should never happen because Mendel's law of independent assortment holds for any two genes we consider E. The genes responsible for the phenotypes we are observing are "linked," i.e., located near each other on the same chromosome - ansE. The genes responsible for the phenotypes we are observing are "linked," i.e., located near each other on the same chromosome How can information about recombination frequencies be used to make a genetic map? - ansAssume that genes that are farther apart will show higher recombination frequencies A genetic map of chromosomes based on recombination frequencies - ansLinkage map What is the formula for recombination frequency? - ans(# of recombinants/ total # of Offspring) x 100 In experiments with two fruit fly characters like those we just learned about, suppose that the raJo of the two parental types and the two recombinant types was 1:1:1:1. What would the recombination frequency be? A. 25% B. 50% C. 75% D. 100%
E. not enough information given - ansB. 50% What can explain a recombination frequency of 50%? - ansGenes that are far apart on the same chromosome behave as if they are unlinked Can multiple crossover events PER chromosome occur? - ansYes. And these an affect observed recombination frequencies. What is a nucleic acid? - ansA polymer made of nucleotide monomers. What is the 5' and 3' end of DNA? - ans5' End- Sugar phosphate backbone 3' End- Sugar (deoxyribose) A nucleotide consists of: - ans1. A nitrogenous base
E. Half of its cells - ansB. All All of the cells in your body have basically the same genome Successful transcription requires 3 basic processes: - ans1. Initiation
****However, most symptoms & damage come from your own immune system!!! Apoptosis, inflammation, etc. Why can't we take antibiotics to successfully cure ourselves of viral infections? A. Viruses evolve resistance too quickly B. Viruses use our own cellular machinery C. Viruses are smarter than bacteria D. Viruses get inside our cells E Viruses replicate too quickly - ansB. Viruses use our own cellular machinery Why are vaccines effective in preventing viral illnesses? A. Vaccines are just like antibiotics B. Vaccines teach your immune system how to recognize specific viruses C. Vaccines make it impossible for a virus to enter your body D Vaccines change your cells so that no virus can enter them E. Vaccines add "virus-fighting" genes to your genome - ansB. Vaccines teach your immune system how to recognize specific viruses Why don't all influenza A viruses readily jump back and forth between humans, birds, pigs, dogs, etc? - ansMost viruses are host specific; specializing to infect one species can make a virus unable to infect another How do different viruses get mixed up? - ansReassortment: possible when multiple virus types infect the same individual host and get into the same cell.... think "viral sex" What are vaccines? - ansDerivatives of pathogenic microbes that stimulate the immune system to mount defenses against the actual microbe A mutation in DNA which causes a change in one letter of a codon could: A. have no effect B. change one amino acid in a protein C. cause a protein to have fewer amino acids than normal D. cause a protein to have more amino acids than normal E. all of the above - ansE. All Suppose a mutation in DNA cause a stop codon to appear prematurely in an mRNA transcript. What effect would this have? A. Cause a shortened version of the protein to be produced B. No effect C. Cause a different amino acid to appear in the protein at the location corresponding to this codon D. Cause a longer version of the protein to be produced - ansA. Shortened version How do DNA mutations alter proteins? - ans1. Substitution: Switching one nucleotide for another
D.3' C A U G C C G G U A A C G 5' - ansC. Read 5' to 3' Complimentary base pairing How do we know what "reading frame" to use/ Where to start translating the mRNA and how to break it into codons? - ansSome kind of "start" signal in the mRNA sequence.... The first codon (AUG) establishes the start point and the reading frame Which of the following types of cells in your body has a gene for eye color? A. Eye cells only B. Toe cells C. Gametes only D. Brain cells E. All of the above - ansE. All cells are pretty much the same! What would need to happen in order for a healthy adult human to make more insulin? A. "Turn on" expression of the insulin gene in cells in the pancreas B. Activate pancreatic stem cells to differentiate to make more pancreatic cells C. "Turn on" the human insulin operon - ansA. "Turn on" expression of the insulin gene in cells in the pancreas ** Can't be C because only bacteria have operons Given what you know about eukaryotic gene regulation: To turn on expression of the insulin gene in pancreatic cells, what would be needed? A. A signal directly from the brain to each cell in the pancreas B. The sight, smell, and taste of a donut C. The right combination of transcription factors to promote expression of the insulin gene D. A mutation in the insulin gene - ansC. The right combination of transcription factors to promote expression of the insulin gene How does "Coordinate Control" (accomplishing multiple parts of regulation in concert) differ in Bacteria vs. Eukaryotes? - ans1. Bacteria
Dideoxyribonucleotides terminate DNA synthesis because they... A. Do not properly form complementary base pairs B. Can not be incorporated by DNA polymerase C. Lack a 3'=OH group preventing additional nucleotides from being added D. Cause the breakdown of the template strand - ansC. Lack a 3'=OH group preventing additional nucleotides from being added How is evolution defined? - ansChange over time in a populations genetic makeup Descent with modification Evolution refers to both patterns and processes. How do they differ? - ans1. Patterns