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: CYTRIC ACID CYCLE:
-The citric acid cycle (Krebs cycle or tricarboxylic acid—TCA
cycle) is the most important metabolic pathway for the
energy supply to the body.
- ATP is synthesized in Krebs cycle. Citric acid cycle
essentially involves the oxidation of acetyl CoA to CO2 and
H2o.
Brief History-
The citric acid cycle was proposed by Hans Adolf
Krebs in 1937, based on the studies of oxygen
consumption in pigeon breast muscle.
Location of TCA Cycle:
The enzymes of TCA cycle are located in mitochondrial
matrix, in close proximity to the electron transport chain.
TCA Cycle—An Overview: Krebs cycle basically
involves the combination of a two-carbon acetyl CoA with a
four- carbon oxaloacetate to produce a six- carbon
tricarboxylic acid, citrate.
• Oxaloacetate is considered to play a catalytic role in
citric acid cycle.
