BIOMEDICAL SENSING
(Nano-bio-sensors)
Diego A Gomez-Gualdron
Texas A&M University
February 23rd, 2010
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Biomedical Sensing: Nano-bio-sensors and Biomarker Detection using Label-Free Nanosensors, Slides of Nanotechnology
The concept of biomedical sensing, focusing on nano-bio-sensors and their application in detecting biomarkers related to diseases such as prostate cancer and kidney malfunction. The importance of sensing, various sensing applications, and the use of label-free nanosensors for point-of-care testing. The document also covers the fet nanosensor technology, its functioning, and its application in ph sensing and antibody sensing.
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BIOMEDICAL SENSING
(Nano-bio-sensors)
Diego A Gomez-Gualdron Texas A&M University February 23 rd^ , 2010
Introduction
Sensing means becoming aware of…
Sensors applications
The primary goal is detect danger so an action can be
taken… Gas concentration Pressure sensing
sensing
We need a property that correlates to what I want to measure
What I want to measure in medicine?
The concentration of a biomarkers can tell me the
nature of a disease and what stage it is in
WHITE CELLS INFECTION
CREATININE
KIDNEY
MALFUNCTION
Nanosensors
If I want to measure
something small, I need
something small…
Nanosensor technology
LABEL-FREE LABEL
In labeled technology, some sort of label has to be
attached to the biomarker, which otherwise would
pass by undetected…
Why would I prefer a label-free
approach?
1. One fewer step to worry about (labeling)
2. I do not need a device to excite and image the
sample
3. I might create a lab-on-a-chip device
4. I would end-up with point of care (POC) testing
Point of care testing
test results treatment
SCENARIO A
SCENARIO B
Wait results treatment
Proof-of concept
Performed by Lieber et al (Science 293 , 1289, 2001)…
nanowire
Science 293 , 1289, 2001
pH Sensing
It is a good start to demonstrate the sensibility to
‘superficial’ charge changes…
Science 293 , 1289, 2001
Why it works
Antigens appear during
disease and can be used
as biomarkers
Nature has made the binding
between antibodies and
antigens very specific
A simple model
Analytical Chemistry (2006), 2093-
Si Nanoribbons as nanosensors
Introduced by Linnros et al (Nanoletters, 8, 3, 945-949 (2008))…
Nanoletters, 8, 3, 945-949 (2008)
It behaves like a Schottky barrier
Antibody sensing
Once again, the biotin-streptavidin system is studied… the nanoribbon is functionalized with biotin (biotinalized) and the solution contains streptavidin at different concentrations…
biotin
streptavidin
Si Nanoribbon
Nanoletters, 8, 3, 945-949 (2008)
Modified from Science 293 , 1289, 2001